What is a Mycobacterium phage?
By Penelope Carter
What is a Mycobacterium phage?
Abstract. Mycobacteriophages are viruses that infect mycobacterial hosts. A large number of mycobacteriophages have been isolated and genomically characterized, providing insights into viral diversity and evolution, as well as fueling development of tools for mycobacterial genetics.
What are Actinophages?
Filters. Any bacteriophage that infects bacteria of the order Actinomycetales. noun. 1.
What are phage clusters?
In categorizing phages we use the term ‘clusters’ for groups of similar phages according to the usage of Hatfull and co-workers (Hatfull et al., 2010; Hatfull et al., 2013) and to avoid confusion with previously used terms such as ‘types’, ‘groups’ or current formal taxonomic classifications.
What is the sea phages program?
SEA-PHAGES (Science Education Alliance-Phage Hunters Advancing Genomics and Evolutionary Science) is a two-semester, discovery-based undergraduate research course that begins with simple digging in the soil to find new viruses, but progresses through a variety of microbiology techniques and eventually to complex genome …
What is Actinophage?
Medical Definition of actinophage : a bacteriophage that develops in and lyses an actinomycete.
What is phage genomics?
The minimal genome of tailed phages encodes DNA packaging, head, tail and tail fibers, DNA replication, transcription regulation, and lysis genes. These genetic functions can be squeezed into a 20 kb DNA genome as demonstrated by c2 Siphovirus and φ29 Podovirus.
What are phage clusters based on?
Currently mycobacteriophages, a highly studied phage group, are categorized into related clusters based on the comparative analysis of whole genome sequences.
What is the goal of the sea-phages program?
The SEA-PHAGES Program The program aims to increase undergraduate interest and retention in the biological sciences through immediate immersion in authentic, valuable, yet accessible research.
What are mycobacteriophage used for?
Historically, mycobacteriophage have been used to “type” (i.e. “diagnose”) mycobacteria, as each phage infects only one or a few bacterial strains. In the 1980s phages were discovered as tools to genetically manipulate their hosts.
How many mycobacteriophages have been isolated from tuberculosis?
While originally isolated from the bacterial species Mycobacterium smegmatis and Mycobacterium tuberculosis, the causative agent of tuberculosis, more than 4,200 mycobacteriophage have since been isolated from various environmental and clinical sources. 2,042 have been completely sequenced.
What is an example of a bacteriophage?
A bacteriophage found to infect Mycobacterium smegmatis in 1947 was the first documented example of a mycobacteriophage. It was found in cultures of the bacteria originally growing in moist compost. The first bacteriophage that infects M. tuberculosis was discovered in 1954.
What is the genetic diversity of mycobacteriophages?
Genetic studies with mycobacteriophage Giles show that 45% of the genes are nonessential for lytic growth. Figure 1. Diversity of mycobacteriophages. Sequenced genomes for 471 mycobacteriophages were compared according to their shared gene contents and overall nucleotide sequence similarity.
