Does MGUS cause neuropathy?
By Gabriel Cooper
Does MGUS cause neuropathy?
Peripheral neuropathy (PN) is a reported complication of MGUS and 20% of newly diagnosed MM patients present with PN. These MM patients are more likely to develop more severe PN during treatment with certain drugs used to treat MM (e.g. bortezomib and thalidomide).
What are the symptoms of LCDD?
People with LCDD make too many light chains, which get deposited in many body tissues. While LCDD can occur in any organ, the kidneys are always involved. Signs and symptoms of LCDD may include protein in the urine; decreased kidney function; and/or nephrotic syndrome.
How is light chain deposition disease treated?
The goal of treating LCDD is to slow the production of light chains and their damage to organs. Treatment may include chemotherapy with a drug called Bortezomib; autologous stem cell transplantation; immunomodulatory drugs; and/or kidney transplant. If untreated, end-stage renal disease occurs in 70% of cases.
Can light chain disease be cured?
Treatment. Decreasing production of the organ-damaging light chains is the treatment goal. Options include chemotherapy using bortezomib, autologous stem cell transplantation, immunomodulatory drugs, and kidney transplant. There is no standard treatment for LCDD.
Is light chain disease the same as multiple myeloma?
Light chain amyloidosis is also a disorder of abnormal plasma cell growth, but with lower amounts of abnormal plasma cells in the bone marrow compared to multiple myeloma. Monoclonal proteins (antibodies) are made up of joined protein chains – 2 short light chains and 2 longer heavy chains.
Is light chain disease hereditary?
In the usual type of immunoglobulin light-chain amyloidosis (AL), no hereditary pattern has been identified, and the disease is considered “sporadic.” The only definite requirement for amyloid formation appears to be a plasma cell dyscrasia that produces excess monoclonal amyloid fibril precursor protein.
