Are cytotoxic drugs cell cycle specific?
By Matthew Alvarez
Are cytotoxic drugs cell cycle specific?
Chemotherapy drugs that kill cancer cells when they are at rest are called cell-cycle non-specific. The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective. This is why chemotherapy is typically given in cycles.
How do cell cycle specific drugs work?
These drugs act specifically by blocking the ability of a cancer cell to divide and become two cells. Although they act throughout the cell cycle, some are more effective during the S- and M- phases, making these drugs cell cycle specific.
What is the classification of cytotoxic drugs?
These drugs target DNA or metabolic steps which are crucial for cell division, thus leading to apoptosis (cytotoxic). They are broadly classified as alkylating agents, antimetabolites, natural products, and miscellaneous drugs.
How does cytotoxic chemotherapy work?
A cytotoxic drug is a substance that results in cell damage or cell death. During the chemotherapy process, the chemotherapy drug enters the blood stream and circulates throughout the body, targeting rapidly dividing cells.
What is meant by a cycle of chemotherapy?
A cycle means that you have a single cancer drug or a combination of drugs and then have a rest to allow your body to recover. You might have some chemotherapy injections over a day or two and then have some time with no treatment. The treatment and rest time make up one treatment cycle.
What are cytotoxic drugs?
Cytotoxic drugs (sometimes known as antineoplastics) describe a group of medicines that contain chemicals which are toxic to cells, preventing their replication or growth, and so are used to treat cancer. They can also be used to treat a number of other disorders such as rheumatoid arthritis and multiple sclerosis.
How are cytotoxic drugs administered?
cytotoxic drugs should be prescribed, dispensed, and administered only in the context of a written protocol or treatment plan. injectable cytotoxic drugs should only be dispensed if they are prepared for administration. oral cytotoxic medicines should be dispensed with clear directions for use.
